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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CAD All Species: 22.42
Human Site: T1974 Identified Species: 54.81
UniProt: P27708 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P27708 NP_004332.2 2225 242984 T1974 S M F Y E V S T R T S S S F A
Chimpanzee Pan troglodytes XP_001155357 2225 242993 T1974 S M F Y E V S T R T S S S F A
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_540124 2288 250188 T2037 S M F Y E V S T R T S S S F A
Cat Felis silvestris
Mouse Mus musculus Q8C196 1500 164599 I1276 K T L G V D F I D V A T K V M
Rat Rattus norvegicus P07756 1500 164561 I1276 K T L G V D F I D V A T K V M
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001009884 2230 247184 T1980 S M F Y E V S T R T S S S F A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P05990 2224 246654 D1990 G G R V I S M D N I T S S V K
Honey Bee Apis mellifera XP_393888 2241 249499 T1990 T I F Y E V S T R T S C S F A
Nematode Worm Caenorhab. elegans NP_495838 2198 242563 Y1971 T V Q V L G S Y G D I L V L R
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P07259 2214 245107 T1961 T I F F E P S T R T C S S F I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 N.A. 94.8 N.A. 36.2 36.3 N.A. N.A. N.A. N.A. 76.8 N.A. 64.5 63.6 57.8 N.A.
Protein Similarity: 100 100 N.A. 95.8 N.A. 48.5 48.6 N.A. N.A. N.A. N.A. 86 N.A. 77.4 78 73.3 N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 0 0 N.A. N.A. N.A. N.A. 100 N.A. 13.3 80 6.6 N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 13.3 13.3 N.A. N.A. N.A. N.A. 100 N.A. 20 93.3 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 51.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 69 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 60 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 20 0 0 0 50 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 10 10 0 0 0 % C
% Asp: 0 0 0 0 0 20 0 10 20 10 0 0 0 0 0 % D
% Glu: 0 0 0 0 60 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 60 10 0 0 20 0 0 0 0 0 0 60 0 % F
% Gly: 10 10 0 20 0 10 0 0 10 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 20 0 0 10 0 0 20 0 10 10 0 0 0 10 % I
% Lys: 20 0 0 0 0 0 0 0 0 0 0 0 20 0 10 % K
% Leu: 0 0 20 0 10 0 0 0 0 0 0 10 0 10 0 % L
% Met: 0 40 0 0 0 0 10 0 0 0 0 0 0 0 20 % M
% Asn: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 10 0 0 0 0 0 60 0 0 0 0 0 10 % R
% Ser: 40 0 0 0 0 10 70 0 0 0 50 60 70 0 0 % S
% Thr: 30 20 0 0 0 0 0 60 0 60 10 20 0 0 0 % T
% Val: 0 10 0 20 20 50 0 0 0 20 0 0 10 30 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 50 0 0 0 10 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _